THC-P Study Reveals the Most Powerful Cannabinoid

THC-P Study Reveals the Most Powerful Cannabinoid

In the newly discovered THC-P molecule, researchers found a critical side chain in the molecule’s structure that is elongated with seven links. Naturally occurring cannabinoids with more than five links in the side chain have not yet been detected in cannabis. 

The length of this side chain has been shown to play a critical role in the effects THC exerts over the body’s CB1 receptors. A minimum of three links is necessary to bind THC to the receptor, with binding affinity peaking at eight links before it starts to decrease in activity again.

THC-P’s elongated side chain appears to have an even stronger affinity for the CB1 receptor than regular THC, which suggests it can work its magic more potently. 

THC-P from the Beginning

THC-P was first shown to the world on in 2019 via a Scientific Reports journal. THC-P was discovered by accident. A study was conducted by a team of Italian researchers. They used advanced mass-spectrometry and liquid chromatography technology on a natural (not synthetic) cannabis sample (FM2) provided by the Military Chemical Institute in Florence, Italy.

The mass-spectrometry and liquid chromatography analysis allowed the researchers to analyze the plant matter precisely. During this process, THC-P was discovered by accident. It is denoted that THC-P is thirty times more effective than THC at binding with CB1 receptors.

A cannabinoid with more than five atoms has never been previously reported as naturally occurring, as noted by the authors of the study. A cannabinoid with more than five atoms is also challenging to isolate.

Statistics Show THC-P is More Potent

Tetrahydrocannabiphorol is a phytocannabinoid, one of the hundreds of active compounds that cannabis plants produce in their resinous trichomes. Scientists have identified almost 150 of these chemicals to date, and THC-P is a relatively new cannabinoid on the list.

THC-P is thought to be more potent because of the way it binds to cannabinoid receptors. THC-P bound strongly to both receptors at a strength 33 times more powerful than regular THC on the CB1 receptor and 5-10 times more active than regular THC on the CB2 receptor. THC-P was also shown to be 63 times stronger than another cannabis compound called THCV.


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